Reactive oxygen species-dependent down-regulation of ubiquitin C-terminal hydrolase in Schizosaccharomyces pombe
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چکیده
منابع مشابه
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is selectively and abundantly expressed in the brain, and its activity is required for normal synaptic function. Here, we show that UCH-L1 functions in maintaining normal synaptic structure in hippocampal neurons. We found that UCH-L1 activity is rapidly upregulated by NMDA receptor activation, which leads to an increa...
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Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1, aka PGP9.5) is an abundant, neuronal deubiquitinating enzyme that has also been suggested to possess E3 ubiquitin-protein ligase activity and/or stabilize ubiquitin monomers in vivo. Recent evidence implicates dysregulation of UCH-L1 in the pathogenesis and progression of human cancers. Although typically only expressed in neurons, high levels o...
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Schizosaccharomyces pombe cells of strains each carrying a deletion of one of the genes snf5, ypa1, pho7 and pas1 and of a strain overexpressing gene odr1, have been previously shown to grow in presence of the toxic glucose analogue 2-deoxyglucose (2-DG). Here we report that these genes control 2-DG induced lysis and are, with the exception of odr1, also involved in control of formation of reac...
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Role of ubiquitin C-terminal hydrolase L1 (UCHL1) in brain function: Ubiquitin is used by a variety of cellular systems to tag proteins for transport to various organelles. There are a number of enzymes in the ubiquitin-proteasome pathway (UPP) that tag abnormally folded proteins with ubiquitin for transport to the proteasome for degradation. UCHL1 is a neuron-specific enzyme constituting over ...
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Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by tremor, bradykinesia, postural instability and muscular rigidity. Neuropathologically, it is defined by cell loss in the substantia nigra associated with the presence of intraneuronal inclusions called Lewy bodies (LB) and processes engorged with proteinaceous material, the Lewy neurites. The recent identi...
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ژورنال
عنوان ژورنال: The Korean Journal of Microbiology
سال: 2016
ISSN: 0440-2413
DOI: 10.7845/kjm.2016.6025